Parathyroid hormone (PTH) receptors and the biological response to PTH in osteoblasts have been shown to be influenced by glucocorticoids, growth factors, cytokines or PTH itself. Furthermore, components of extracellular matrix (ECM) appear to regulate the response to PTH as well. We investigated th
Involvement ofc-fosgene in the regulation of osteoblast proliferation and osteoclast differentiation by parathyroid hormone and parathyroid hormone-related protein
β Scribed by Junichi Kano; Toshitsugu Sugimoto; Masanori Kanatani; Hiroshi Kaji; Toru Yamaguchi; Masaaki Fukase; Kazuo Chihara
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 464 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0914-8779
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## Abstract We have previously reported that parathyroid hormone (PTH) and PTH related protein (PTHrP) stimulate expression of interleukinβ6 (ILβ6) and leukemia inhibitory factor (LIF) in osteoblasts in vitro. In the current study, we have developed a model of hormone injection into the subcutaneou
The involvement of multiple G-proteins in parathyroid hormone regulation of acid production was demonstrated in a highly enriched osteoclast population. Osteoclasts were isolated from the endosteum of 2.5 to 3-week-old chicken tibia using sequential enzymatic digestion. Single cell analysis of acid
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