Secretion of a growth inhibitory factor by ZR-75-1 human breast cancer cells
β Scribed by Rosalyn Blumenthal; William McLaughlin; Jerold Jordan; Ellen Cryan; William Bloomer
- Book ID
- 115760154
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 388 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0006-291X
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Polyamine transport is strongly induced by insulin and estradiol (E,) in ZR-75-I human breast cancer cells. Because signal transduction mechanisms of insulin and interleukin-4 (IL-4) partly overlap, we have compared the ability of these agents as well as that of interleukin-I3 (lL-l3), a cytokine th
## Abstract Our study demonstrates that quercetin (Q)βinduced growthβinhibitory activity in ovarian cancer cells may be mediated by modulation of transforming growth factor Ξ²~1~ (TGFΞ²~1~) production. We used the OVCA 433 cell line which is very sensitive to the antiβproliferative effect of Q and ex