Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: Antagonism by insulin
β Scribed by Richard Poulin; Jean -Marc Dufour; Fernand Labrie
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 884 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The insulinβlike growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBPβ1 purified from human amniotic fluid neutralizes IGFβIβdependent growth of MCFβ7 cells. In thi
Polyamine transport is strongly induced by insulin and estradiol (E,) in ZR-75-I human breast cancer cells. Because signal transduction mechanisms of insulin and interleukin-4 (IL-4) partly overlap, we have compared the ability of these agents as well as that of interleukin-I3 (lL-l3), a cytokine th
Since estrogens play a predominant role in the development and growth of human breast cancer, antiestrogens represent a logical approach to the treatment of this disease. The present study compares the effects of the novel nonsteroidal anti-estrogen EM-800 and related compounds with those of a serie