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Secreted Wnt “inhibitors” are not just inhibitors: Regulation of extracellular Wnt by secreted Frizzled-related proteins

✍ Scribed by Yusuke Mii; Masanori Taira

Book ID
108944306
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
579 KB
Volume
53
Category
Article
ISSN
0012-1592

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## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol