## Abstract Mechanisms controlling human bone formation remain to be fully elucidated. We have used differential display‐polymerase chain reaction analysis to characterize osteogenic pathways in conditionally immortalized human osteoblasts (HOBs) representing distinct stages of differentiation. We
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
✍ Scribed by Peter V.N. Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A. Bhat; Annamarie Mangine; Laura M. Seestaller-Wehr; Robert A. Moran; Julia Billiard; Shoichi Fukayama; Barry S. Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C. Kern; Thomas J. Commons; Richard P. Woodworth; Matthew A. Wilson; Gregory S. Welmaker; Eugene J. Trybulski; William J. Moore
- Book ID
- 116321538
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 706 KB
- Volume
- 44
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Secreted frizzled‐related proteins (sFRPs) are glycoproteins that are recognized as Wnt antagonists. To identify the functional domains that are involved in Wnt antagonist function, several sFRP‐1 mutants and sFRP‐1/sFRP‐2 chimeras were generated. These mutants were characterized in an
## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol
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