The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation
โ Scribed by Yoon-Sook Lee; Kyoo-A Lee; Hae-Bom Yoon; Seung-Ah Yoo; Young Woo Park; Yeonseok Chung; Wan-Uk Kim; Chang-Yuil Kang
- Book ID
- 112082231
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 1019 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0014-2980
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## Abstract ## BACKGROUND. The secreted frizzledโrelated protein 1 gene (__SFRP1__) encodes a Wnt/ฮฒโcatenin signaling antagonist and frequently is inactivated by promoter methylation in many tumors. However, the role of __SFRP1__ in hepatocellular carcinoma (HCC) is not clear. Therefore, the autho
## Abstract Canonical Wnt signaling (ฮฒโcatenin/TCF) has emerged as a key regulator of skeletogenesis. In this study, chondrogenesis is examined in a mouse model in which the Wnt antagonist secreted frizzled related protein 1 (sFRP1) is nonโfunctional and results in a high bone mass phenotype and ac