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Secretases as targets for the treatment of Alzheimer's disease: the prospects

✍ Scribed by Ilse Dewachter; Fred Van Leuven

Book ID
114407196
Publisher
The Lancet
Year
2002
Tongue
English
Weight
725 KB
Volume
1
Category
Article
ISSN
1474-4465

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## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we