𝔖 Bobbio Scriptorium
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Secretases as targets for the treatment of Alzheimer’s disease

✍ Scribed by Martin Citron

Book ID
114381875
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
191 KB
Volume
6
Category
Article
ISSN
1357-4310

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β-secretase as a target for the treatment of Alzheimer's disease
✍ Martin Citron 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 1 views

## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we