๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Searching for drug targets in microbial genomes

โœ Scribed by Michael Y Galperin; Eugene V Koonin


Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
279 KB
Volume
10
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


In vivo drug target discovery: identifyi
โœ D.Wade Walke; Chunsheng Han; Joseph Shaw; Elisabeth Wann; Brian Zambrowicz; Arth ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 81 KB

A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function i

Protein-interaction mapping in search of
โœ Amitabha Chaudhuri; John Chant ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 524 KB

## Abstract Signaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surro

Probing the genome for new drugs and tar
โœ Jim Lillie ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 126 KB ๐Ÿ‘ 1 views

Automated fluorescent sequencers have now generated full and partial sequences of several eukaryotic genomes. How can we best use this information to discover new drugs? One important tool is mRNA expression profiling with DNA arrays. Large-scale high-density DNA arrays can be created for hybridizat

Mouse Genetics/Genomics: An Effective Ap
โœ David B. West; Olga Iakougova; Christine Olsson; David Ross; Jeffrey Ohmen; Alu ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 540 KB

The mouse has become the premier mammalian system for the identification of the genetic basis of both mono-and oligogenic disorders, as well as the understanding of complex diseases with gene-gene and gene-environment interactions. The similarity between human and mouse genetic disease is sometimes

Advances in genomics for microbial food
โœ Willem M de Vos ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 65 KB

The exponentially growing collection of genomic sequence information, the high-throughput analysis of expression products, and the ability to order this information using advanced bioinformatics are expected to affect biotechnology and life sciences in a profound and unprecedented way. These develop