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In vivo drug target discovery: identifying the best targets from the genome

✍ Scribed by D.Wade Walke; Chunsheng Han; Joseph Shaw; Elisabeth Wann; Brian Zambrowicz; Arthur Sands

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
81 KB
Volume
12
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.

✦ Synopsis

A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.

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