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Probing the genome for new drugs and targets with DNA arrays

✍ Scribed by Jim Lillie

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
126 KB
Volume
41
Category
Article
ISSN
0272-4391

No coin nor oath required. For personal study only.

✦ Synopsis

Automated fluorescent sequencers have now generated full and partial sequences of several eukaryotic genomes. How can we best use this information to discover new drugs? One important tool is mRNA expression profiling with DNA arrays. Large-scale high-density DNA arrays can be created for hybridization experiments with complex probes to determine in one experiment the level of mRNA expression of each arrayed gene. Genes regulated during a physiological response or disease state can now be quickly identified and become candidates for more intense investigation. Conversely, patterns of expression levels can be used as assays for every step in the drug discovery and development process, from target discovery through clinical evaluation. This review summarizes the opportunity presented by combining EST sequencing data with mRNA expression profiling with DNA arrays to find new ways of discovering drugs.

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