New drug targets for depression and anxiety: Is the peptides era arriving?

✍ Scribed by David Gurwitz; Abraham Weizman

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 65 KB
• Volume: 65
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.20012

✦ Synopsis

Abstract

The monoamine theory of mood disorders has dominated psychiatric dogma for nearly 50 years. Recent findings about the role of brain peptides in the regulation of emotions and behavior challenge this over‐simplified theory, and are about to open the door for a new era, focused on peptides as putative complementary drug targets in psychiatry. The development of improved animal models for depression would accelerate its arrival. Drug Dev. Res. 65:93–96, 2005. © 2005 Wiley‐Liss, Inc.