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SCREENING TEST FOR ATAXIA TELANGIECTASIA

✍ Scribed by Schindler, Detlev; Seyschab, Helga; Poot, Martin; Hoehn, Holger; Schinzel, Albert; Fryns, JeanPierre; Tommerup, Niels; Rabinovitch, PeterS.


Book ID
121996683
Publisher
The Lancet
Year
1987
Tongue
English
Weight
293 KB
Volume
330
Category
Article
ISSN
0140-6736

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Epidemiological studies have suggested that ataxia-telangiectasia (AT) heterozygotes have a predisposition to cancer, especially breast cancer in women. Now, haplotyping can identify heterozygotes for AT mutation (ATM) in AT families, allowing the risk of cancer associated with ATM heterozygosity st