0-21. Screening for mutations in ataxia-telangiectasia gene in breast cancer patients
โ Scribed by J. Ramsay; G. Birrell; S. Kozlov; C. Pyke; M. Lavin
- Book ID
- 114317027
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 138 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-9776
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The ataxia-telangiectasia mutated (ATM) gene, which is mutated in the autosomal recessive disorder ataxia-telangiectasia (AT), was isolated in 1995 by positional cloning. Although in vitro cell fusion studies had suggested that AT was genetically heterogeneous, all AT patients studied to date have b
Communicated by Steve S. Sommer ATM has been identified as a gene that is responsible for ataxia telangiectasia (AT), a pleiotropic disorder of autosomal recessive inheritance. While many mutations of this gene in AT patients of various ethnicities have been reported, data on Japanese patients are s