Screening of Protein-Ligand Interactions by Affinity Chromatography
✍ Scribed by Carlos D. García; Steven C. Holman; Charles S. Henry; W. William Wilson
- Book ID
- 109386694
- Publisher
- American Institute of Chemical Engineers
- Year
- 2003
- Tongue
- English
- Weight
- 96 KB
- Volume
- 19
- Category
- Article
- ISSN
- 8756-7938
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📜 SIMILAR VOLUMES
## Abstract Affinity chromatography of proteins requires a ligand covalently bound to a solid support separated by a spacer of sufficient length. In the specific case of acetyl‐cholinesterase we have reduced the conventional spacer synthesis from five to three steps. For affinity chromatography of
## Abstract The development of rational design criteria for synthetic‐ligand‐based affinity chromatography requires a basic comprehension of all the factors influencing the binding capacity and selectivity of the stationary phase. In this work, molecular dynamics simulations are systematically used