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Screening hydroxynitrile lyases for (R)-pantolactone synthesis

✍ Scribed by Beate Pscheidt; Manuela Avi; Richard Gaisberger; Franz S. Hartner; Wolfgang Skranc; Anton Glieder

Book ID
113804280
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
318 KB
Volume
52-53
Category
Article
ISSN
1381-1177

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The hydroxynitrile lyase (HNL)-catalysed cyanohydrin reaction is a useful method to synthesize enantiopure -hydroxy nitriles and the corresponding -hydroxy acids. 1,2 However, small ketones, such as 2-butanone, are converted with low selectivities, due to the poor discrimination between methyl and e