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Practical Methods for Biocatalysis and Biotransformations || Synthesis of Cyanohydrins Using Hydroxynitrile Lyases

โœ Scribed by Whittall, John; Sutton, Peter

Publisher
John Wiley & Sons, Ltd
Year
2009
Weight
377 KB
Category
Article
ISBN
0470519274

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โœฆ Synopsis

The hydroxynitrile lyase (HNL)-catalysed cyanohydrin reaction is a useful method to synthesize enantiopure -hydroxy nitriles and the corresponding -hydroxy acids. 1,2 However, small ketones, such as 2-butanone, are converted with low selectivities, due to the poor discrimination between methyl and ethyl. [3][4][5] Recently, the synthesis of (S)-2-hydroxy-2-methylbutyric acid has been reported using the docking/protecting group concept 6 and HNL from Hevea brasiliensis (HbHNL) as catalyst (Scheme 8.

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โœ Whittall, John; Sutton, Peter ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley & Sons, Ltd โš– 476 KB ๐Ÿ‘ 2 views

Dihydroxyacetone phosphate (DHAP)-dependent aldolases are powerful catalysts for synthesis of carbohydrates and related compounds, such as iminocyclitols. Their utility is limited by the strict requirement for DHAP, an expensive, unstable compound, as donor substrate. The DHAP-dependent rhamnulose-1