Screening for variants of the uncoupling protein 2 gene in Japanese patients with non—insulin-dependent diabetes mellitus
✍ Scribed by Tomoko Shiinoki; Tadashi Suehiro; Yukio Ikeda; Mari Inoue; Toshihiro Nakamura; Yoshitaka Kumon; Yuh Nakauchi; Kozo Hashimoto
- Book ID
- 117180762
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 385 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1532-8600
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Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec
Type 2 (non-insulin-dependent) diabetes is associated with the deposition of islet amyloid. The major formative peptide, islet amyloid polypeptide, has recently been characterised and an abnormality of the structure or expression of this gene is a possible candidate for the inherited component of Ty