Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec
โฆ LIBER โฆ
Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNALeu(UUR)genes
โ Scribed by N. Iwasaki; H. Ohgawara; H. Nagahara; M. Kawamura; G. I. Bell; Y. Omori
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 628 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0940-5429
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The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restrict