Molecular screening of the glucokinase gene in familial Type 2 (non-insulin-dependent) diabetes mellitus
β Scribed by S. C. Elbein; M. Hoffman; H. Qin; K. Chiu; Y. Tanizawa; M. A. Permutt
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 817 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0012-186X
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Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec
The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA pro
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