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Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family

✍ Scribed by Szilvia Solyom; Robert Winqvist; Jenni Nikkilä; Katrin Rapakko; Pasi Hirvikoski; Hannaleena Kokkonen; Katri Pylkäs


Book ID
116335584
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
720 KB
Volume
302
Category
Article
ISSN
0304-3835

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Since the identification of the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2, a large number of different germline mutations in both genes have been found by conventional PCR-based mutation detection methods. Complex germline rearrangements such as those reported in the BRCA1 gene