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54 Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families

✍ Scribed by S. Solyom; K. Pylkäs; R. Winqvist


Book ID
119601844
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
46 KB
Volume
8
Category
Article
ISSN
1359-6349

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Since the identification of the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2, a large number of different germline mutations in both genes have been found by conventional PCR-based mutation detection methods. Complex germline rearrangements such as those reported in the BRCA1 gene