Genomic rearrangements of the BRCA1 gene in Chilean breast cancer families: an MLPA analysis
β Scribed by Alejandro Sanchez; Paola Faundez; Pilar Carvallo
- Book ID
- 106379188
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 464 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0167-6806
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π SIMILAR VOLUMES
The presence of genomic rearrangements of the BRCA1 gene in breast and/or ovarian cancer families has been intensively investigated in patients from various countries over the last years. A number of different rearrangements have been reported by several studies that clearly document the involvement
Here we report the study on BRCA1 and BRCA2 mutations in 12 Thai breast and/or ovarian cancer families and 6 early-onset breast or breast/ovarian cancer cases without a family history of cancer. Five distinct rare alterations were identified in each gene: four introducing premature stop codons, one