The presence of genomic rearrangements of the BRCA1 gene in breast and/or ovarian cancer families has been intensively investigated in patients from various countries over the last years. A number of different rearrangements have been reported by several studies that clearly document the involvement
โฆ LIBER โฆ
The contribution of LARGE genomic rearrangements of BRCA1 and BRCA2 gene mutations in breast and ovarian cancer families in a clinical cohort
โ Scribed by S Sawyer; S Boyle; MA Young; S Kovalenko; R Doherty; J McKinley; K Alsop; M Rehfisch; S Macaskill; A Ha; V Beshay; G Lindeman; M Harris; S Fox; G Mitchell; P James
- Book ID
- 115027849
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 80 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1897-4287
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The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo