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Screening for inherited mutations in the Czech high risk breast cancer patients – analysis of 400 families

✍ Scribed by Z. Kleibl; P. Pohlreich; J. Stribrna; J. Soukupova; I. Ticha; M. Mateju; M. Zikan; J. Novotny; J. Kotlas; J. Sevcik

Book ID
119598853
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
85 KB
Volume
6
Category
Article
ISSN
1359-6349

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There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications