Screening for EVI1: ectopic expression absent in T-cell acute lymphoblastic leukemia patients and cell lines
β Scribed by A. De Weer; B. Poppe; B. Cauwelier; N. Van Roy; N. Dastugue; A. Hagemeijer; A. De Paepe; F. Speleman
- Book ID
- 113513006
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 53 KB
- Volume
- 171
- Category
- Article
- ISSN
- 0165-4608
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The relationship between karyotype and expression of the T-cell receptor (TCR) proteins was examined in I9 patients with T-lineage acute lymphoblastic leukemia (T-ALL). All patients expressed CD3 molecules in the cytoplasm or on the cell membrane. Patients were classified according t o TCR expressio
TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL