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Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines

โœ Scribed by Kaoru Inoue; Takashi Kohno; Satoshi Takakura; Yasuhide Hayashi; Hideaki Mizoguchi; Jun Yokota

Book ID
114119730
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
315 KB
Volume
24
Category
Article
ISSN
0145-2126

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Microsatellite instability (MSI) represents a defect in the DNA mismatch repair system and has been shown to take part in the genesis and/or progression of several human malignancies. In hematological malignancies, the relevance of MSI has been a matter of controversy. Therefore, 29 microsatellite l