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Screening for APC Mutations Based on Detection of Truncated APC Proteins

✍ Scribed by Osamu Tominaga; Marcelo Eidi Nita; Hirokazu Nagawa; Tetsuichiro Muto


Book ID
110377261
Publisher
Springer US
Year
1998
Tongue
English
Weight
251 KB
Volume
43
Category
Article
ISSN
0163-2116

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About 80% of the mutations identified to date in the Adenomatous Polyposis Coli (APC) gene have been found in the 5' half of the coding sequence, the vast majority of which (>95%) are nonsense or frameshift mutations that result in the loss of the carboxyl terminus of APC protein. Using a stop codon