APC gene mutations play a role in the initiation step of colorectal carcinogenesis in both familial adenomatous polyposis (FAP) and non-FAP patients. Almost all of the APC mutations are nonsense or frameshift mutations, which truncate the APC protein and are thought to inactivate normal APC function
β¦ LIBER β¦
Screening for APC Mutations Based on Detection of Truncated APC Proteins
β Scribed by Osamu Tominaga; Marcelo Eidi Nita; Hirokazu Nagawa; Tetsuichiro Muto
- Book ID
- 110377261
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 251 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0163-2116
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About 80% of the mutations identified to date in the Adenomatous Polyposis Coli (APC) gene have been found in the 5' half of the coding sequence, the vast majority of which (>95%) are nonsense or frameshift mutations that result in the loss of the carboxyl terminus of APC protein. Using a stop codon
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