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Rapid detection of APC mutations in FAP families and colorectal tumors by protein truncation test

โœ Scribed by R.B. van der Luijt; P. Meera Khan; H.F.A. Vasen; C.M.J. Tops; C. van Leeuwen; C. Breukel; P.A.M. Roest; J.T. den Dunnen; I.S.J. van Leeuwen-Cornelisse; R. Fodde


Book ID
119106230
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
86 KB
Volume
77
Category
Article
ISSN
0165-4608

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Detection of APC mutations by a yeast-ba
โœ Takao Suzuki; Chikashi Ishioka; Satoshi Kato; Yasushi Mitachi; Hideki Shimodaira ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 154 KB

APC gene mutations play a role in the initiation step of colorectal carcinogenesis in both familial adenomatous polyposis (FAP) and non-FAP patients. Almost all of the APC mutations are nonsense or frameshift mutations, which truncate the APC protein and are thought to inactivate normal APC function