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Sclerostin inhibition increases bone mass and bone defect regeneration in rats with type 2 diabetes mellitus

✍ Scribed by C. Hamann⁎; Y. Höhna; M. Rauner; J. Mettelsiefen; C. Göttsch; R. Bernhardt; K.-P. Günther; M.S. Ominsky; L.C. Hofbauer

Book ID
116325308
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
95 KB
Volume
50
Category
Article
ISSN
8756-3282

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## Abstract The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass, and bone strength in an aged, gonad‐intact male rat model. Sixteen‐month‐old male Sprague‐Dawley rats were injected subcutaneou