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Inhibition of sclerostin by treatment with anti-sclerostin antibody increased cancellous bone formation and decreased bone resorption in both high and low turnover bone sites in female rats

✍ Scribed by X.Y. Tian; W.S.S. Jee; R.B. Setterberg; M. Chen; X. Li; W.S. Simonet; C. Paszty; H.Z. Ke

Book ID: 116320707
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 71 KB
Volume: 43
Category: Article
ISSN: 8756-3282
DOI: 10.1016/j.bone.2008.07.030

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## Abstract The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass, and bone strength in an aged, gonad‐intact male rat model. Sixteen‐month‐old male Sprague‐Dawley rats were injected subcutaneou