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Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model

✍ Scribed by XiaoYan Tian; Webster S.S. Jee; Xiaodong Li; Chris Paszty; Hua Zhu Ke


Book ID
116323621
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
544 KB
Volume
48
Category
Article
ISSN
8756-3282

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## Abstract The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass, and bone strength in an aged, gonad‐intact male rat model. Sixteen‐month‐old male Sprague‐Dawley rats were injected subcutaneou