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Sclerostin antibody increased modeling-based bone formation and decreased bone resorption on endocortical surfaces in male cynomolgus monkeys

✍ Scribed by M.S. Ominsky⁎; Q.-T. Niu; H.Z. Ke


Book ID
116325195
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
88 KB
Volume
50
Category
Article
ISSN
8756-3282

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Two doses of sclerostin antibody in cyno
✍ Michael S Ominsky; Fay Vlasseros; Jacquelin Jolette; Susan Y Smith; Brian Stouch 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 691 KB

## Abstract The development of bone‐rebuilding anabolic agents for treating bone‐related conditions has been a long‐standing goal. Genetic studies in humans and mice have shown that the secreted protein sclerostin is a key negative regulator of bone formation. More recently, administration of scler