Schwann cell growth factors
β Scribed by Raff, Martin C.; Abney, Erika; Brockes, Jeremy P.; Hornby-Smith, Ann
- Book ID
- 123057030
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 949 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
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## Abstract Cultured Schwann cells divide in response to a limited repertoire of mitogens. In addition to cyclic AMP analogs and reagents that raise intracellular cyclic AMP, the only purified mitogens for Schwann cells are transforming growth factor beta (TGFΞ²), acidic (a) and basic (b) fibroblast
## Abstract Transplantation of Schwann cells (SCs) and olfactory ensheathing cells (OECs) have emerged as very promising therapies for spinal cord repair. The important features of interaction between SCs and OECs are beginning to be appreciated, although the underlying mechanism remains unclear. I
Most previous studies on Schwann cell proliferation in vitro have used serum-containing media. This complicates the analysis of agents required for cell division since serum contains an ill-defined mixture of hormones and growth factors. Serum-free medium has therefore been used to analyse the respo
To examine the role of platelet-derived growth factor (PDGF) in the in vivo regulation of Schwann cell proliferation, steady-state levels of mRNAs encoding PDGF A and B chains, and PDGF a and p receptors were measured in immature and adult rat sciatic nerves and in cultured rat Schwann cells. PDGF B