Glial growth factor—like activity in Schwann cell tumors
✍ Scribed by Jeremy P. Brockes; Xandra O. Breakefield; Dr Robert L. Martuza
- Book ID
- 102706164
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 622 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0364-5134
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Both neurons and glia succumb to programmed cell death (PCD) when deprived of growth factors at critical periods in development or following injury. Insulin-like growth factor-I (IGF-I) prevents apoptosis in neurons in vitro. To investigate whether IGF-I can protect Schwann cells (SC) from apoptosis
Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are interested in the role of insulin-like growth factor-I (IGF-I) in SC developm