Dopamine D 1 -receptor binding in the basal ganglia is differentially regulated by subtype nonspecific dopamine antagonists such as the antipsychotic, Fluphenazine. The purpose of the present study was to determine the relative contributions of D 1 and D 2 receptor systems in the regulation of basal
SCH 23390: The First Selective Dopamine D1-Like Receptor Antagonist
β Scribed by James A. Bourne
- Book ID
- 109105578
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 191 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1080-563X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A new synthesis is described for the production of the positron emitting radiopharmaceutical R-(+)-7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-N-[11C]methyl-1-phenyl-1H- 3-benzazepine (SCH 23390, 2a). This novel method involves reductive carboxylation, in which [11C]CO2 is reacted with the trimethylsily
The optimal conditions for the synthesis of 11C-labelled SCH 23390 by radio-methylation of its desmethyl precursor, SCH 24518, with [11C]iodomethane are described. Isocratic reversed phase HPLC was used for the purification of [11C]SCH 23390. The specific activity range in 30 runs was 10-235 Ci/mmol