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Synthesis of [11C]SCH 23390 for dopamine D1 receptor studies

✍ Scribed by O.T. DeJesus; G.J.C. Van Moffaert; A.M. Friedman

Publisher
Elsevier Science
Year
1987
Weight
365 KB
Volume
38
Category
Article
ISSN
0883-2889

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✦ Synopsis

The optimal conditions for the synthesis of 11C-labelled SCH 23390 by radio-methylation of its desmethyl precursor, SCH 24518, with [11C]iodomethane are described. Isocratic reversed phase HPLC was used for the purification of [11C]SCH 23390. The specific activity range in 30 runs was 10-235 Ci/mmol and average radiochemical yield was 72% based on [11C]iodomethane. Mean synthesis time was 40-60 min from the end of bombardment. Preliminary animal studies indicate that [11C]SCH 23390 would be useful in visualizing D1 receptors in a living brain by positron tomography.

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