Synthesis of a radiobrominated analog of SCH 23390, a selfctive dopamine D1/DA1 antagonist

✍ Scribed by Onofre T. De Jesus; Glenn J. Van Hoffaert; Dana Glock; Leon I. Goldber; Arnold H. Friedman

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: French
• Weight: 289 KB
• Volume: 23
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580230902

✦ Synopsis

A r a d i o b r o d n a t e d analog of SCH 23390, a s e l e c t i v e dopamine D1/DAI a n t a g o n i s t was prepared. were obtained w i t h i n 15 minutes r e a c t i o n a t r o m temperature. The s y n t h e s i s was v a l i d a t e d by performing both p h y s i c a l (MR and mass spectroscopy) and b i o l o g i c a l tests on t h e product. s t u d i e s suggest t h a t 75Br-labelled SCH 23390 analog would be a u s e f u l ligand f o r t h e s t u d i e s of CNS dopamine D1 r e c e p t o r s by p o s i t r o n emission tomography. R a d i o c h c d c a l y i e l d s of up t o 60%