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Scaffold-Hopping Cascade Yields Potent Inhibitors of 5-Lipoxygenase

✍ Scribed by Bettina Hofmann; Lutz Franke; Ewgenij Proschak; Yusuf Tanrikulu; Petra Schneider; Dieter Steinhilber; Gisbert Schneider


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
313 KB
Volume
3
Category
Article
ISSN
1860-7179

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Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-Ξ³-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,