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SAT-5-2 The discovery and pharmacology of xanomeline, a muscarinic M1 receptor agonist for Alzheimer's disease

✍ Scribed by H.E. Shannon; E.P. Bymaster; D.O. Calligaro; N.W. DeLapp; C.H. Mitch; J.S. Warc; P. Olesen; M.J. Sheardown; M.D.B. Swedberg; P. Sauerberg

Book ID
119176027
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
138 KB
Volume
5
Category
Article
ISSN
0924-977X

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Xanomeline: A selective muscarinic agoni
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✍ Frank P. Bymaster; Celia A. Whitesitt; Harlan E. Shannon; Neil DeLapp; John S. W πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 147 KB πŸ‘ 3 views

Xanomeline is a novel muscarinic receptor agonist relatively devoid of parasympathomimetic side effects. Xanomeline had high affinity for muscarinic receptors and much lower affinity for a variety of other neuronal receptors in radioligand binding assays. Functional studies in cell lines transfected