The functional selectivity of WAL 2014 FU with regard to stimulation of the neuronal muscarinic M 1 receptor subtype in vitro and in vivo is shown in different receptor preparations, isolated organ models, whole animal testing, and finally humans. From receptor binding experiments in membrane prepar
Talsaclidine (WAL 2014 FU), a muscarinic M1 receptor agonist for the treatment of Alzheimer's disease
β Scribed by Marion Wienrich; Angelo Ceci; Helmut A. Ensinger; Wolfram Gaida; Klaus D. Mendla; Takeshi Osugi; Andreas Raschig; Thomas Weiser
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 212 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0272-4391
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## Abstract Selective muscarinic agonists might be useful in the treatment of Alzheimer's disease. To help characterize the activity and functional selectivity of two M~1~ muscarinic agonists, secretion of amyloid precursor protein, brain penetration, side effect profiles, cognitionβenhancing prope