This study evaluated the safety and efficacy of combined treatment with E-aminocaproic acid or tranexamic acid and monoclonal antibody purified factor IX (MAb factor IX) for prophylaxis against bleeding in eight hemophilia B patients undergolng nine dental extraction procedures. Ail patients achieve
β¦ LIBER β¦
Safety of high doses of a monoclonal antibody-purified factor IX concentrate
β Scribed by Dr. Indira Warrier; Carol K. Kasper; Gilbert C. White II; Amy D. Shapiro; Garrett E. Bergman
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 210 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
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## Abstract There is concern that shear could cause protein unfolding or aggregation during commercial biopharmaceutical production. In this work we exposed two concentrated immunoglobulinβG1 (IgG1) monoclonal antibody (mAb, at >100 mg/mL) formulations to shear rates between 20,000 and 250,000 s^β1
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