Safety and efficacy of purified factor IX concentrate and antifibrinolytic agents for dental extractions in hemophilia B
✍ Scribed by Djulbegovic, Benjamin; Marasa, Mary; Pesto, Al; Kushner, George M.; Hadley, Terence; Joseph, Geetha; Goldsmith, George
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 215 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
This study evaluated the safety and efficacy of combined treatment with E-aminocaproic acid or tranexamic acid and monoclonal antibody purified factor IX (MAb factor IX) for prophylaxis against bleeding in eight hemophilia B patients undergolng nine dental extraction procedures. Ail patients achieved excellent hemostasis without clinical evidence of thrombosis. There were no significant changes in hemoglobin or hematocrit or in markers of hemostatic system activation (prothrombin fragment F,+2, fibrinopeptide A, and fragment Bp,,) after surgery. Thus, a highly purified factor IX concentrate and antifibrinolytic therapy can be effectively and safely combined in hemophilia B patients undergoing dental extractions.