Safety and efficacy of subcutaneous and continuous intravenous infusion rIL-2 in patients with metastatic renal cell carcinoma
β Scribed by Geertsen, P F; Gore, M E; Negrier, S; Tourani, J M; von der Maase, H
- Book ID
- 109998008
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 138 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ## BACKGROUND The objective of this study was to determine the response rate and toxicity of gemcitabine and continuousβinfusion 5βfluorouracil (5βFU) in combination with subcutaneous interleukinβ2 (IL2) and interferonβΞ± (IFNA) in patients with metastatic renal cell carcinoma. ## METH
## RESULTS. Fifty-five patients were enrolled in the trial and 52 were evaluable for ogy, The University of Texas M. D. Anderson response. All patients experienced fever and flu-like symptoms. Grade 3 or 4 nonhe-Cancer Center, Houston, Texas. matologic toxic effects included hypertension (48%), d