Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma
✍ Scribed by Gaston, R; Oskam, R; Philip, T; Ravaud, A; Négrier, S; Cany, L; Merrouche, Y; Le Guillou, M; Blay, JY; Clavel, M
- Book ID
- 109836994
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 876 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0007-0920
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## Abstract We investigated the biological response of 73 patients with metastatic renal‐cell carcinoma (MRCC) treated by repetitive weekly cycles of high‐dose interleukin 2 (IL‐2) (protocol 1, 40 patients) or IL‐2 plus interferon‐gamma (IFN‐γ) (protocol 2, 33 patients). The objectives of this stud
Background. Prolonged therapy with interferon (IFN) may lead to the formation of IFN antibodies. Methods. Patients with renal cell carcinoma (n = 270) with advanced localized disease were randomized after complete tumor resection to receive treatment with adjuvant recombinant IFN-alpha-2a (rIFN-a2a