## BACKGROUND. The treatment of patients with metastatic renal cell carcinoma (RCC) continues to pose a major clinical challenge. Previous studies have suggested that infusional floxuridine (FUDR) has antitumor efficacy and is well tolerated. To the authors knowledge the combination of infusional F
Simplified chronomodulated continuous infusion of floxuridine in patients with metastatic renal cell carcinoma
✍ Scribed by Thierry Conroy; Lionnel Geoffrois; Francois Guillemin; Elisabeth Luporsi; Ivan Krakowski; Dominique Spawëth; Véronique Frasie; Dominique Volff
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 776 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
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Background. Twenty-nine patients with metastatic renal cell carcinoma (RCC) were treated with constantinfusion floxuridine (FUdR, Roche Laboratories, Nut-Methods. The initial dosage was 0.075 mg/kg/day for 14 days every 28 days and was increased or decreased by 0.025-mg/kg/day increments at each sub
## RESULTS. Fifty-five patients were enrolled in the trial and 52 were evaluable for ogy, The University of Texas M. D. Anderson response. All patients experienced fever and flu-like symptoms. Grade 3 or 4 nonhe-Cancer Center, Houston, Texas. matologic toxic effects included hypertension (48%), d