𝔖 Bobbio Scriptorium
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Sa.125. Dendritic Cell Activation by Tumour Cell-Derived Exosomes

✍ Scribed by Liz Ilett; Fiona Errington; Ruth Morgan; Richard Vile; Peter Selby; Alan Melcher

Book ID
113539266
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
51 KB
Volume
119
Category
Article
ISSN
1090-2341

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Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo. In vi