Proteoglycans (PGs) were extracted from human hypertrophic and normal scar tissues from two different stages of maturation after bum injury, under dissociative conditions (4 M guanidinium chloride containing proteinase inhibitors). The extracts were fractionated by ion-exchange chromatography, follo
S5.18 Iduronic acid-rich proteoglycans and post-burn scar maturation: Isolation and characterization
โ Scribed by H. G. Garg; J. W. Siebert; P. J. Neame
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 119 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1573-4986
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Small proteoglycans (PGs), extracted from human keloid scar tissue with 4M guanidinium chloride and fractionated by DEAE-cellulose chromatography, were separated by ethanol precipitation into one L-iduronic acid-rich and one D-glucuronic acid-rich fraction. The size of the L-iduronic acid-rich PG wa
Hypertrophic scarring is characterized by disordered collagen fibrils. In order to determine whether this is, in part, a result of changes in the population of proteoglycans that are thought to be involved in regulation of collagen fibril formation, we have compared PGs from post-bum normal and hype