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S1002 Amino Acid Substitutions in Core Region of Hepatitis C Virus Genotype 1b Predict Poor Response to Pegylated-Interferon-Alpha 2b and Ribavirin Combination Therapy

✍ Scribed by Hayashi, Kazuhiko; Katano, Yoshiaki; Honda, Takashi; Nakano, Isao; Kumada, Takashi; Goto, Hidemi

Book ID: 123117996
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 97 KB
Volume: 134
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(08)63607-0

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## Abstract The efficacy of interferon (IFN) monotherapy for non‐responders to pegylated interferon (PEG‐IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who rec