✦ LIBER ✦

S100 protein and down syndrome

✍ Scribed by Alexander Marks; Robert Allore

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 431 KB
Volume: 12
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950120806

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✦ Synopsis

SlOO protein is a low molecular weight calcium-binding protein widely distributed in the central nervous system of vertebrates. Recent evidence suggests that SlOO protein may play a role in the regulation of glial proliferation and neuronal differentiation. The gene for SlOO protein has been mapped to the 21q22 region, a chromosomal locus whose duplication has been implicated in the generation of Down Syndrome (DS). This raises the possibility that abnormalities in SlOO protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS.

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